New research by Nestlé scientists has revealed the potential dual impact NAD+ supplementation can have on our cellular energy and gut microbiome. This study will help guide the development of future nutrition solutions to support healthy longevity, which has been identified as a key growth platform for the company, the company stated in a release.
NAD+ (nicotinamide adenine dinucleotide) is a key co-enzyme that plays a role in keeping the cells in our bodies functioning properly throughout our lives. It is important for energy production, DNA repair and certain cellular functions. However, our NAD+ levels naturally decrease as we age, and low NAD+ levels are associated with health conditions such as cognitive decline, cardiovascular problems, muscle loss and sleep disturbances. One of the areas most impacted by reduced cellular energy is the gut microbiome, which plays a crucial role in modulating our health as we age, from immunity to neurological function, the company said.
The study findings, recently published in the journal Nature Metabolism, indicate that people who take NAD+ supplementation could experience benefits beyond boosting their NAD+ levels by promoting microbial growth and production of beneficial metabolites, Nestle said.
The researchers compared three NAD+ precursors, NR (nicotinamide riboside), NMN (nicotinamide mononucleotide), and Nam (nicotinamide) to provide a better understanding of how NAD+ precursors behave in the human body. They found for the first time that a 14-day supplementation of NR and NMN comparably increases circulatory NAD+ concentrations in healthy adults, while Nam supplementation does not. They also observed that NR and NMN interact with gut microbiota, producing nicotinic acid and enhancing microbial activity.
“This is the first clinical study directly comparing different NAD+ precursors showing that NR and NMN supplementation can similarly increase NAD+ levels in healthy adults and may also support gut health,” said Prof Eline van der Beek, head of the Nestlé Institute of Health Sciences. “These findings deepen our understanding of how NAD+ precursors can support healthy aging at the cellular level and pave the way for the development of innovative solutions to support healthy longevity.”
Nestlé has recently announced the strengthening of its R&D expertise in cutting-edge biotechnology and clinical research to bolster consumer-centric innovations that support healthier lives across all life stages, including during aging.
The company has launched several nutritional supplements in recent years designed to improve cellular health and support healthy longevity. For example, nicotinamide riboside can be found in the Solgar Cellular Nutrition Cellular Energy and Pure Encapsulations NR Longevity supplements from Nestlé Health Science.
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Naresh Khanna – 10 February 2025
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